사업단소개 > 연구진 소개
 
사  진
연구실동호   21-411
연구실전화   880-7869
실험실전화   880-7868
연구실Fax   872-3632
전자우편   lbj@nmr.snu.ac.kr
홈페이지   http://www.snupharm.ac.kr/lbj/
성  명   이봉진 (李奉振) 대학원전공   약제과학
생년월일   1958
학  력
Ph. D., Osaka University
주요연구분야
생체 고분자의 구조-기능 관계 연구를 통한 신약 개발
1. Peptide 공학에 의한 peptide 약물 개발
2. 약물 수용체의 구조-기능 관계 연구
3. 약물개발을 위한 단백질 공학
대표논문자료
Lee SK, Chio KH, Lee SJ, Suh SW, Kim BM, Lee BJ Peptide Deformylase Inhibitors with Retro-amide Scaffold: Synthesis and Structure-Activity Relationships. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 20(15), pp. 4317-4319 (2010.08)

Han JH, Choi YS, Kim WJ, Jeon YH, Lee SK, Lee BJ, Ryu KS, Codon Optimization Enhances Protein Expression of Human Peptide Deformylase in E. coli. PROTEIN EXPRESSION AND PURIFICATION 70(2), pp. 224-230 (2010.04)

Won HS, Kang SJ, Lee BJ, Action mechanism and structural requirements of the antimicrobial peptides, gaegurins. Biochimica et Biophysica Acta-Biomembranes 1788, pp. 1620-1629 (2009.08)

Kim JH, Park SJ, Lee KY, Son WS, Sohn NY, Kwon AR, Lee BJ, Solution structure of hypothetical protein HP1423 (Y1423_HELPY) reveals the presence of alpha L motif related to RNA binding. PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS 75(1), pp. 252-257 (2009.04)

Seo MD, Seok SH, Im H, Kwon AR, Lee SJ, Kim HR, Cho Y, Park D, Lee BJ, Crystal structure of the dimerization domain of human filamin A. PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS 75, pp. 258-263 (2009.04)

Hong YH, Ahn HC, Lim J, Kim HM, Ji HY, Lee S, Kim JH, Park EY, Song HK, Lee BJ, Identification of a novel ubiquitin binding site of STAM1 VHS domain by NMR spectroscopy. FEBS Letters 583(2), pp. 287-292 (2009.01)

박성진, 서민덕, 이숙경, 이봉진, Membrane binding properties of EBV gp110 C-terminal domain; evidences for structural transition in the membrane environment., VIROLOGY, (2008.09)

Kim HR, Lee GH, Ha KC, Ahn T, Moon JY, Lee BJ, Cho SG, Kim S, Seo YR, Shin YJ, Chae SW, Reed JC, Chae HJ, Bax Inhibitor-1 Is a pH-dependent Regulator of Ca2+ Channel Activity in the Endoplasmic Reticulum. Journal of Biological Chemistry 283(23), pp. 15946-15955 (2008.06)

한경두, 박성진, 장선복, 이봉진, Solution structure of conserved hypothetical protein HP0892 from Helicobacter pylori., PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS 70(2), pp. 599-602 (2008.02)

Won HS, Seo MD, Jung SJ, Lee SJ, Kang SJ, Son WS, Kim HJ, Park TK, Park SJ, Lee BJ, Structural Determinants for membrane Interaction of Novel Bioactive Undecapeptides derived from Gaegurin 5. Journal of Medicinal Chemistry 49(16) pp. 4886-95 (2006.08)

Won HS, Jung SJ, Kim HE, Seo MD, Lee BJ, Systematic Peptide Engineering and Structural Characterizati. Journal of Biological Chemistry 275(19), pp. 14784-91 (2004)

Hyung-Sik Won, Yeon-Hee Lee, Ji-Hun Kim, In-Seon Shin, Man-Hyung Lee, Bong-Jin Lee, Structure characterization of the Nickel-binding properties of bacillus pasteurii UreE in solution, Journal of Biological Chemistry 279(17), pp. 17466-72 (2004.04)

Ahn HC, Ohkubo T, Iwai S, Morikawa K, Lee BJ, Interaction of T4 Endonuclease V with DNA: IMPORTANCE OF THE FLEXIBLE LOOP REGIONS IN PROTEIN-DNA INTERACTION. Journal of Biological Chemistry 278(33), pp. 30985-92 (2003.08)

Park SH, Kim HE, Kim CM, Yun HJ, Choi EC, Lee BJ, Role of proline, cysteine and a disulphide bridge in the structure and activity of the anti-microbial peptide gaegurin 5. Biochemical Journal 368 pp. 171-82 (2002.11)

Won HS, Lee TW, Park SH, Lee BJ, Stoichiometry and structural effect of the cyclic nucleotide binding to cyclic AMP receptor, Journal of Biological Chemistry 264(19), pp. 11450-57 (2002.03)

Won HS, Yamazaki T, Lee TW, Yoon MK, Park SH, Kyogoku Y, Lee BJ, Structural Understanding of the Allosteric Conformational Change of Cyclic AMP Receptor Protein by the Cyclic AMP Binding, Biochemistry 39(45), pp. 13953-62 (2000.11)

A. Toyama, E. Kurashiki, Y. Watanabe, H. Takeuchi, I. Harada, H. Aiba, Bong Jin Lee, Y. Kyogoku, Ultraviolet Resonance Raman Spectra of Cyclic AMP Receptor Protein. Journal of the American Chemical Society 113, pp. 3615-16 (1991.04)